Born in 1959 in Antwerp, Belgium, Alÿs originally trained as an architect. He moved to Mexico City in 1986, where he continues to live and work, and it was the confrontation with issues of urbanization and social unrest in his new country of adoption that inspired his decision to become a visual artist. Since 2004, the artist’s work has been represented by David Zwirner, where he has had two solo exhibitions at the gallery in New York in 2007 and 2013. In 2016, Ciudad Juárez projects marked his first solo presentation at David Zwirner, London and, in 2021, the solo exhibition Don't Cross the Bridge Before You Get to the River was on view at the gallery's Paris location.

Throughout his practice, Francis Alÿs consistently directs his distinct poetic and imaginative sensibility toward anthropological and geopolitical concerns centered around observations of, and engagements with, everyday life, which the artist himself has described as “a sort of discursive argument composed of episodes, metaphors, or parables.” His multifaceted projects including public actions, installations, video, paintings, and drawings­ have involved traveling the longest possible route between locations in Mexico and the United States; pushing a melting block of ice through city streets; commissioning sign painters to copy his paintings; filming his efforts to enter the center of a tornado; carrying a leaking can of paint along the contested Israel/Palestine border; and equipping hundreds of volunteers to move a colossal sand dune ten centimeters.